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Adult HIV prevalence in Tanzania is estimated at 4.5 percent (UNAIDS 2021), with regional HIV prevalence ranging from 0.5 percent (Zanzibar) to 11.4 percent (Njombe). Tanzania has a generalized HIV epidemic but there are also concentrated sub-epidemics among key populations. Women and girls continue to be disproportionately affected compared to men, with adolescent girls and young women accounting for 80 percent of all new HIV infections. USAID works to mitigate the impact and spread of Tanzania’s HIV epidemic in partnership with the Government of Tanzania, other U.S. Government agencies, and a wide range of implementing partners through the President’s Emergency Plan for AIDS Relief (PEPFAR).