Since the start of the pandemic, the impacts of COVID-19 have been many. They have included reduced access to nutritious foods, severe disruptions in food supply chains, accelerated democratic backsliding, widened economic inequalities, accelerated aggravation of the global education crisis,4 and increased strain on water systems.5 COVID-19 has had short-term effects, and will continue to have long-term effects across a range of sectors in countries around the world. These effects may potentially counter development gains, including those related to gender equality, such as increasing women’s vulnerability to food insecurity and malnutrition, widening gender poverty gaps, increasing incidence of gender-based violence, exacerbating burdens of unpaid work, increasing exposure and risk of COVID-19 for frontline workers, hindering women’s access to sexual and reproductive health services, and intensifying forms of violence and discrimination. Not considering the potential gendered impacts in USAID’s COVID-19 response will diminish the effectiveness of measures to control the spread of illness and mitigate its impacts similar to previous pandemics. Identifying key issues and implementing recommendations from a COVID-specific gender analysis (CSGA) provide an important opportunity for the United States Agency for International Development (USAID) to address these gender gaps in activities, regardless of where they are in the program cycle, as they respond to COVID-19.